Diosmin Basic information |
Pharmacological Effects |
Product Name: |
Diosmin |
Synonyms: |
DIOSMETIN-7-O-RUTINOSIDE;DIOSMETIN-7-RUTINOSIDE;DIOSMIN;BAROSMIN;Diovenor;DIOSIMIN;BAROSMIN hplc;3',5-Dihydroxy-4'-methoxy-7-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavone |
CAS: |
520-27-4 |
MF: |
C28H32O15 |
MW: |
608.54 |
EINECS: |
208-289-7 |
Product Categories: |
Plant extracts;Herb extract;plant extract;ACTIVE PHARMACEUTICAL INGREDIENTS;Aromatics;CITRIMORE;Tetra-substituted Flavones;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;DIOSMIL;Inhibitors;API |
Mol File: |
520-27-4.mol |
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Diosmin Chemical Properties |
Melting point |
277-278°C |
Boiling point |
926.8±65.0 °C(Predicted) |
density |
1.68±0.1 g/cm3(Predicted) |
vapor pressure |
0Pa at 20ºC |
storage temp. |
Sealed in dry,2-8°C |
solubility |
Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides. |
form |
neat |
pka |
6.10±0.40(Predicted) |
color |
Pale Beige to Brown |
Water Solubility |
Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C). |
λmax |
345nm(EtOH)(lit.) |
Merck |
14,3297 |
InChIKey |
GZSOSUNBTXMUFQ-YFAPSIMESA-N |
LogP |
0.14 at 20ºC |
CAS DataBase Reference |
520-27-4(CAS DataBase Reference) |
Hazard Codes |
Xi |
Risk Statements |
36/37/38 |
Safety Statements |
26-36-36/37-24/25 |
WGK Germany |
3 |
HS Code |
29381000 |
Uses |
Diosmin is an agonist of the aryl hydrocarbon receptor (AhR) and exhibits anti-proliferative and anti-inflammatory. It is used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD). Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). It effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells |
Shipping |
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