| Choline glycerophosphate Basic information |
| Product Name: |
Choline glycerophosphate |
| Synonyms: |
2-[[(2R)-2,3-dihydroxypropoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium;L-A-GLYCEROPHOSPHORYLCHOLINE FROM*EGG YOLK FREE FORM;L-A-GLYCEROPHOSPHORYLCHOLINE FROM SOYBEAN, FREE FORM;L-α-GLYCERYLPHOSPHORYLCHOLINE(GPC);,hydroxide,innersalt,(r)-;L-a-Glycerophosphorylcholine (anhydrous) (GPC);L-α-Glycerophosphorylcholine;GLYCERYLPHOSPHOCHOLINE |
| CAS: |
28319-77-9 |
| MF: |
C8H20NO6P |
| MW: |
257.22 |
| EINECS: |
248-962-2 |
| Product Categories: |
GPC;Smart drug;Activity Other;Activity;Enzyme Substrates;pharmaceutical ingredients;28319-77-9 |
| Mol File: |
28319-77-9.mol |
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| Choline glycerophosphate Chemical Properties |
| Melting point |
142.5-143° |
| alpha |
D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8) |
| Boiling point |
480ºC[at 101 325 Pa] |
| vapor pressure |
0Pa at 25ºC |
| Fp |
11 °C |
| storage temp. |
-20°C |
| solubility |
DMSO (Slightly, Heated, Sonicated), (Sparingly), Water (Sparingly) |
| form |
solid |
| color |
White to Off-White |
| Water Solubility |
1000g/L at 25ºC |
| Stability: |
Very Hygroscopic |
| InChI |
InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3 |
| InChIKey |
SUHOQUVVVLNYQR-SBYBRXNCNA-N |
| SMILES |
P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO |&1:12,r| |
| LogP |
-5.15 at 25ºC |
| CAS DataBase Reference |
28319-77-9(CAS DataBase Reference) |
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| Choline glycerophosphate Usage And Synthesis |
| Description |
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine. |
| Chemical Properties |
Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in and ethanol, and insoluble in , ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method. |
| Originator |
Sandoz; Italfarmaco (Italy) |
| Uses |
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic. |
| Uses |
L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids. |
| Uses |
antiarrhythmic, cardiac depressant |
| Uses |
adenosine is an amino acid. Studies indicate anti-wrinkle and skinsmoothing capacities. Although little is written about its direct skin benefit, adenosine plays an important role in biochemical processes. As adenosine triphosphate (ATP) and adenosine diphosphate (ADP), it is involved in energy transfer, and as cyclic adenosine monophosphate (cAMP) in signal transduction. |
| Shipping |
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