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Product Name |
Terlipressin |
CAS NO. |
910463-68-2 |
Appearance |
powder |
Purity |
99% or customized |
Application |
api |
Usage |
[N-α-Triglycyl-8-lysine]-vasopressin;130: PN: WO2010033207 SEQID: 171 claiMed protein;1-Triglycyl-8-lysine Vasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressinum |
Specification |
1kg 5kg 25kg |
Delivery time |
5-6 days fast delivery free customs clear DDP |
Description
Terlipressin acetate is a novel long-acting synthetic vasopressin reagent,its chemical name is three glycyl lysine vasopressin, it is a prodrug, itself has no activity ,in vivo , it removes three glycyl residues in its N-terminus by aminopeptidase, and slowly "releases" the active lysine vasopressin. It is this "slow release" mechanism that makes it maintain the smooth muscle contraction up to 10 hours after a single administration, whereas the same dose of vasopressin, it can maintain its activity for 20-40 minutes. On the other hand,because of the slow digestion, lysine vasopressin in the circulation cannot reach toxic levels, and usage of terlipressin is safer.Pharmacological effect of terlipressin is splanchnic vascular smooth muscle contraction, and reduction of visceral blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal vein blood flow,and reducing portal pressure, on the other hand it may also reduce plasma renin concentration, thereby increasing the renal blood flow in patients with hepatorenal syndrome, to improve kidney function, and increase urine output. Terlipressin is currently the only drug which is able to increase mortality in patients with esophageal varices bleeding , it is previously mainly used in clinical for the treatment of variceal bleeding, in addition,terlipressin now has also been successfully used for liver and kidney integrated syndrome and refractory shock, it is also likely to play a useful role in the cardiopulmonary resuscitation . Compared with vasopressin, it has a lasting effect, and it does not cause dangerous complications, including promoting fibrinolysis and severe complications in the cardiovascular systems, and the use of it is simple (available intravenous injection), it is more suitable for rescue and treatment of emergent and critical patients
Uses
Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It is used norepinephrine-resistant septic shock and hepatorenal syndrome. It is also used in the treatment of acute variceal bleeding. Terlipressin Acetate 1 mg solution for injection is used for the treatment of: bleeding from dilated (widening) veins in the food pipe leading to your stomach (called bleeding oesophageal varices)
Definition
In clinical trials, the most common side effects of terlipressin administration were paleness, increased blood pressure, peripheral ischemia, abdominal pain, nausea, diarrhea, and headache. Terlipressin related adverse events are common and most of terlipressin related adverse events were mild or moderate, which can be resolved spontaneously without any intervention. As terlipressin acts mainly on the splanchnic vessels, the incidence of severe ischemic complications is lower with terlipressin than with vasopressin. However, it may cause serious complications such as myocardial infarction, intestinal ischemia, peripheral cyanosis, and skin necrosis
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Overseas warehouses in Canada, the United States, Mexico, Australia, Germany, the Netherlands, and Belgium support cash transactions, warehouse pick-up of packages, or private truck delivery. The world's fastest and professional warehousing and transportation team!
Currently we have 6 different warehouses in Germany throughout Europe and three warehouses in the Netherlands. Poland, Spain, Belgium, Hungary. We have a complete warehouse service system. We can ship your package quickly and only takes 1-2 days for delivery. If you have a large package you can pick it up at our warehouse or we can ship it to you quickly with a private truck and deliver it the same day. This is currently the most popular service model for all our clients. We can provide you with exclusive overseas warehouses and customized transportation routes. Looking forward to your consultation and cooperation.
Providing warehousing services at warehouses in Sydney and Melbourne, Australia. We stock a large number of local hot-selling products in our local warehouse. You can collect it from the warehouse or use Australia Post to have it delivered to your parcel locker address. We offer the fastest shipping mode, overnight delivery. Of course we can also deliver large quantities of parcels using private trucking. We have a mature business model in Australia. And gained the trust of a large number of Australian customers. You can buy almost all the best-selling products in the Australian warehouse. All products are privately packaged, safer and faster.
We have established complete warehouses in Vancouver and Toronto, Canada. We stock a large selection of local hot selling products in our local warehouse. You can pick up your package at the warehouse, or have your package delivered using Canada Post, UPS, private truck, etc. We have a mature business model in Canada. And gained the trust of a large number of Canadian customers. If you have a larger market for new products we can pay you after a large quantity of stock arrives at the warehouse.
Product packaging: We provide packaging of different specifications according to customer needs. Meet all customer needs. Different packaging is used for different chemical powders and liquids. We can also do privacy packaging customized according to your requirements. For the most basic packaging, we use aluminum foil bags sealed with double-layer vacuum packaging. We can provide packaging of different specifications: 1Kg 2kg 5Kg 10kg 20kg 25kg 200kg. Use high-hardness cartons and filling materials to avoid product damage during transportation. The customer receives a satisfied product.
Product transportation: We have warehouses in the United States, Canada, Mexico, and Australia and can ship from overseas warehouses. Improve our shipping efficiency. Let customers receive packages quickly. In addition, we have cooperation with international express delivery companies such as FEDEX, UPS, TNT EMS, etc. In addition, we are better at using dedicated air freight lines for transportation. Specializing in the transportation of chemical products and other international logistics. You can receive your package safely. Customers are not required to provide customs clearance information. We provide DDP services. Door to door service. There is no need to sign for the package in person. We have more than ten years of chemical trading experience.
Henan Sigma Audley New Material Technology Co., Ltd. is headquartered in the international metropolis Henan. It is a company dedicated to the research, development, production and sales of organic compounds, pharmaceutical intermediates and chemical raw materials. The company has a long-term partnership with Shanghai Research Institute of Chemical Industry and its affiliated universities. It is a research and development enterprise of new pharmaceutical and chemical materials that adapts to the needs of the global pharmaceutical market. Continuously innovate world-leading new chemical and pharmaceutical products. Integrating innovative drug research and development, industrialization and market operations. The company has strong technical force, advanced equipment, strict quality management system and excellent after-sales service. Over the years, our products have been widely sold to many countries and regions, and we have established stable cooperative relationships with traders and end-users around the world. And relying on a strong logistics system, it has established its own overseas warehouses in the United States, Mexico, Canada, the Netherlands and other places. Local hot-selling products can be shipped from overseas warehouses. Well received by local customers. And has become a solid bridge between suppliers, traders and end users. We look forward to more cooperation with you.
High quality with competitive price
1)standard: enterprise standard
2)all purity≥99%
3)we are manufacturer and can provide high quality products with factory price.
Fast and safe delivery
1)parcel can be sent out in 24 hours after payment. tracking number available
2)secure and discreet shipment. various transportation methods for your choice.
3)customs pass rate ≥99%
4) we have our own agent/re-mailer/distributor who can help us ship our products very fast and safe, and we have stock in there
for transferring.
We have clients throughout the world
1)professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3)high quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.